Endocrine Abstracts

Obesity and type 2 diabetes are expanding rapidly and become a wide world health issue. These metabolic diseases are tightly associated with an insulin resistance state. Among insulin target tissues, liver plays a central role in the regulation of glucose homeostasis.Insulin action is initiated by its binding to its receptors (IR) which, once activated, phosphorylate intracellular substrates and lead to the activation of transduction pathways implicating...